导师简介
简介： 李帅，男，博士研究生，副教授，2021年毕业于中国医科大学。目前承担本科生《无机化学》及研究生《天然化合物结构研究法》等课程。主持国家自然科学基金青年基金、河北省自然科学基金生物医药专项及河北省教育厅青年项目各一项。以第一作者及通讯作者发表SCI论文10余篇，申请发明专利7项。作为副主编及编委参编教材2部。
所招专业：中药学（1008）
主要研究方向：
新型小分子抑制剂的发现及其作用机制研究
主持的科研项目
基于天然来源生物碱的新型PARP-1/FTase双靶点抑制剂的设计、合成及抗KRAS突变肺癌的机制研究（82204210）-国家自然科学基金，2022-2025，主持
基于高刺桐生物碱的新型PARP-1/EZH2双靶点抑制剂的设计、合成及抗BRCA野生型肺癌的机制研究（H2022406062）-河北省自然科学基金,2022-2025，主持
新型苯并螺环类PARP-1抑制剂的设计、合成及生物活性研究（QN2022161）-河北省教育厅，2022-2024，主持
近年来发表代表性论文
1. ClickGen: Directed exploration of synthesizable chemical space via modular reactions and reinforcement learning -Nature communications
2. Development of Erythrina-based PARP-1/FTase dual-target inhibitors against lung cancer epithelial-mesenchymal transition (EMT) in vivo and in vitro -Bioorganic Chemistry
3. Discovery of novel 2,3,4,5-tetrahydrospiro[benzo[c]azepine-1,1'-cyclohexan]-5-ol derivatives as PARP-1 inhibitors -BMC Chemistry
4. Structural classification of EZH2 inhibitors and prospects for the treatment of tumor: a review-Medicinal Chemistry Research
5. FTase inhibitors and cancer: Prospects for use in targeted therapies- Medicinal Chemistry Research
6. Recent advances in structural types and medicinal chemistry of PARP-1 inhibitors- Medicinal Chemistry Research
7. Advances in Structural Types and Pharmacochemistry of CDK12 Inhibitors- Medicinal Chemistry
8. Design, synthesis and biological evaluation of novel EZH2 inhibitors- Russian journal of bioorganic chemistry
9. A Novel 5-Chloro-N-phenyl-1H-indole-2-carboxamide Derivative as Brain-Type Glycogen Phosphorylase Inhibitor: Potential Therapeutic Effect on Cerebral Ischemia-Molecules
10. Novel 4,5-dihydrospiro[benzo[c]azepine-1,1'-cyclohexan]-3(2H)-one derivatives as PARP-1 inhibitors: Design, synthesis and biological evaluation- Bioorganic Chemistry
11. Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM)- Bioorganic Chemistry
12. Design, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors- Bioorganic Chemistry
13. Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs- Bioorganic Chemistry
14. Design and synthesis of benzo-spirocyclic derivatives as potent PARP-1 inhibitors- Russian journal of bioorganic chemistry
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