主要著作及论文 1. 论文 第一作者或通讯作者发表SCI收录10篇，中文核心期刊70余篇，代表性论文如下： [1]Xiulu Guan, Shiyuan Shen, Jinxia Liu, Hongru Song, Jinhua Chang, Xiaoxia Mao, Jingyu Song, Lin Zhang, Cuizhe Liu. Protective effects of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway. BMC Complement Med Ther. 2023, 23(1): 72. [2]Pei Liu, Jian-Yu Zhou, Jin-Hua Chang, Xi-Gang Liu, He-Fei Xue, Ru-Xing Wang, Zhong-Si Li, Chun-Shi Li, Jian Wang*, Cui-Zhe Liu*. Soluplus-mediated diosgenin amorphous solid dispersion with high solubility and high stability: development, characterization and oral bioavailability. Drug Design Development and Therapy, 2020, 14: 2959-2975. [3]Wei, H., Chang, J., Liu, P., Li, Z., Miao, G., Liu, X., Liu, C., & Zhang, X. Design and evaluation of rhubarb total free anthraquinones oral colon-specific drug delivery granules to improve the purgative effect. Brazilian Journal of Pharmaceutical Sciences, 2019, 55, e17110. [4]Jin-hua Chang, Lin Zhang, Xiaodong Gu, Liyan Liu, Zhongsi Li, Guangxin Miao, Xigang Liu, Pei Liu, Hefei Xue, Cuizhe Liu*. The rhubarb total free anthraquinone oral colon-specific drug delivery granules: Comparative pharmacokinetics study with rhubarb by UPLC-MS/MS after oral administration. Journal of Drug Delivery Science and Technology, 2018, 43: 415-422. [5]Lin Zhang, Jinhua Chang, Liyan Liu, Qiang Fu, Cuizhe Liu*. A rapid UPLC-MS/MS method for simultaneous determination of five anthraquinones in rat plasma: Application to a pharmacokinetic study, Acta Medica Mediterranea, 2018, 34(1): 175~180. [6]Ya Xiao, Qiang Zhao, Qian Wu, Jinhua Chang, Hefei Xue, Cuizhe Liu*, Xigang Liu*. A new sensitive UPLC-MS/MS method for the determination of cucurbitacin B in rat plasma:application to an absolute bioavailability study, RSC Advances, 2018, 8: 30978~30985 [7]Pei Liu, Hong-wei Wei, Jinhua Chang, Guangxin Miao, Xigang Liu, Zhongsi Li, Liyan Liu, Xiangrong Zhang, Cuizhe Liu*. Oral colon-specific drug delivery system reduces the nephrotoxicity of rhubarb anthraquinones when they produce purgative efficacy[J]. Experimental and Therapeutic Medicine, 2017, 14(4):3589-3601. [8]Cuizhe Liu*, Jinhua Chang, Lin Zhang, Hefei Xue, Xigang Liu, Pei Liu, Qiang Fu. Preparation and Evaluation of Diosgenin Nanocrystals to Improve Oral Bioavailability, AAPS Pharm SciTech, 2017, 18(6): 2067-2075. [9] Lin Zhang, Jin-hua Chang, Baoqi Zhang, Xigang Liu, Pei Liu, Hefei Xue, Liyan Liu, Qiang Fu, Meng Zhu, Cuizhe Liu*. The pharmacokinetic study on the mechanism of toxicity attenuation of rhubarb total free anthraquinone oral colon-specific drug delivery system[J]. Fitoterapia, 2015, 104(15): 86-96. [10]Cuizhe Liu, Xigang Liu, Jiming Tong, Dawei Chen, Kaishun Bi. Design and evaluation of San-huang dispersible tablet -an efficient delivery system for Traditional Chinese Medicine, Pharmaceutical Development and Technology, 2009, 14(5): 506-515. 2. 授权专利 第一发明人授权发明专利10项，其中美国发明专利1项，欧盟专利1项，中国发明专利8项 （转让2项），一项获河北省优秀发明奖，主要授权专利包括： ①一种黄芩苷镁化合物及其制备方法与它的用途，201610068926.3，中国发明专利，2018.3.6授权。 ②《Baicalin magnesium compound and its preparation method and application》，美国专利号16/052,419，授权日期2019.2.5。 ③《Baicalin magnesium compound and its preparation method and application》，欧盟专利号17746785.9，授权日期2020.8.7。 ④头孢呋辛镁化合物、组合物、制备方法及用途，202010393050.6，中国发明专利，2021.6.8授权。 ⑤一种头孢噻肟镁化合物、其制备方法及应用，202010393332.6，中国发明专利，2022.11.23授权。 |
